Hee Ra Park, Ph.D., graduated in 2013
- POSITION
- 현, 한의학연구소 한약신약개발그룹
[Academic History]
2013 Ph.D., Dept. of Pharmacy, Pusan National University, Korea
2008 M.S., Dept. of Pharmacy, Pusan National University, Korea
2006 B.S., Dept. of Food Nutrition, Sunchon National University, Korea
2013 Ph.D., Dept. of Pharmacy, Pusan National University, Korea
2008 M.S., Dept. of Pharmacy, Pusan National University, Korea
2006 B.S., Dept. of Food Nutrition, Sunchon National University, Korea
- Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model by downregulating the activations of nuclear factor-κB, ERK, and JNK. Lee E, Park HR, Ji ST, Lee Y, Lee J. J Neurosci Res. 2014 Jan;92(1):130-9. doi: 10.1002/jnr.23307. Epub 2013 Oct 28.
- Diallyl disulfide impairs hippocampal neurogenesis in the young adult brain. Ji ST, Kim MS, Park HR, Lee E, Lee Y, Jang YJ, Kim HS, Lee J. Toxicol Lett. 2013 Jul 31;221(1):31-8. doi: 10.1016/j.toxlet.2013.05.013. Epub 2013 May 31.
- Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity. Chung JY, Park HR, Lee SJ, Lee SH, Kim JS, Jung YS, Hwang SH, Ha NC, Seol WG, Lee J, Park BJ. Lab Invest. 2013 Jun;93(6):663-76. doi: 10.1038/labinvest.2013.60. Epub 2013 Apr 22.
- Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption. Lee Y, Oh SB, Park HR, Kim HS, Kim MS, Lee J. Neurosci Lett. 2013 Feb 22;535:134-9. doi: 10.1016/j.neulet.2012.12.050. Epub 2013 Jan 8.
- Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation. Kim HS, Son TG, Park HR, Lee Y, Jung Y, Ishigami A, Lee J. Neurobiol Aging. 2013 Apr;34(4):1177-83. doi: 10.1016/j.neurobiolaging.2012.10.008. Epub 2012 Oct 31.
- Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. Park HR, Kong KH, Yu BP, Mattson MP, Lee J. J Biol Chem. 2012 Dec 14;287(51):42588-600. doi: 10.1074/jbc.M112.406413. Epub 2012 Oct 26.
- Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation. Oh SB, Park HR, Jang YJ, Choi SY, Son TG, Lee J.
Br J Pharmacol. 2013 Jan;168(2):421-31. doi: 10.1111/j.1476-5381.2012.02142.x.
- Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. Choi SY, Son TG, Park HR, Jang YJ, Oh SB, Jin B, Lee J. J Neurosci Res. 2012 Sep;90(9):1842-9. doi: 10.1002/jnr.23061. Epub 2012 Apr 19.
- High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Jang YJ, Park HR, Kim TH, Yang WJ, Lee JJ, Choi SY, Oh SB, Lee E, Park JH, Kim HP, Kim HS, Lee J. Toxicology. 2012 Jun 14;296(1-3):73-82. doi: 10.1016/j.tox.2012.03.007. Epub 2012 Apr 3.
- The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress. Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, Jeon HM, Kang KW, Kang HS, Chang SC, Kim HS, Chung HY, Lee J. Free Radic Res. 2012 Jan;46(1):21-9. doi: 10.3109/10715762.2011.636042. Epub 2011 Nov 22.
- Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Kim MS, Park HR, Chung HY, Kim HS, Yu BP, Yang HS, Lee J. Chem Biol Interact. 2011 Nov 15;194(2-3):139-47. doi: 10.1016/j.cbi.2011.10.001. Epub 2011 Oct 12.
- Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory. Kim ME, Park HR, Gong EJ, Choi SY, Kim HS, Lee J. Food Chem Toxicol. 2011 Dec;49(12):3383-9. doi: 10.1016/j.fct.2011.09.017. Epub 2011 Sep 19.
- Neurogenic contributions made by dietary regulation to hippocampal neurogenesis. Park HR, Lee J. Ann N Y Acad Sci. 2011 Jul;1229:23-8. doi: 10.1111/j.1749-6632.2011.06089.x. Review.
- Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Gong EJ, Park HR, Kim ME, Piao S, Lee E, Jo DG, Chung HY, Ha NC, Mattson MP, Lee J. Neurobiol Dis. 2011 Nov;44(2):223-30. doi: 10.1016/j.nbd.2011.07.005. Epub 2011 Jul 18.
- Lipotoxicity of palmitic Acid on neural progenitor cells and hippocampal neurogenesis.
Park HR, Kim JY, Park KY, Lee J. Toxicol Res. 2011 Jun;27(2):103-10. doi: 10.5487/TR.2011.27.2.103.
- Capsaicin impairs proliferation of neural progenitor cells and hippocampal neurogenesis in young mice. Kong KH, Kim HK, Song KS, Woo YS, Choi WS, Park HR, Park M, Kim ME, Kim MS, Ryu JS, Kim HS, Lee J. J Toxicol Environ Health A. 2010;73(21-22):1490-501. doi: 10.1080/15287394.2010.511572.
- A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. Park HR, Park M, Choi J, Park KY, Chung HY, Lee J. Neurosci Lett. 2010 Oct 4;482(3):235-9. doi: 10.1016/j.neulet.2010.07.046. Epub 2010 Jul 27.
- Risk assessment for the combinational effects of food color additives: neural progenitor cells and hippocampal neurogenesis. Park M, Park HR, Kim SJ, Kim MS, Kong KH, Kim HS, Gong EJ, Kim ME, Kim HS, Lee BM, Lee J. J Toxicol Environ Health A. 2009;72(21-22):1412-23. doi: 10.1080/15287390903212816.
- Potencies of bisphenol A on the neuronal differentiation and hippocampal neurogenesis. Kim K, Son TG, Park HR, Kim SJ, Kim HS, Kim HS, Kim TS, Jung KK, Han SY, Lee J. J Toxicol Environ Health A. 2009;72(21-22):1343-51. doi:10.1080/15287390903212501.
- Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis. Park HR, Kim MS, Kim SJ, Park M, Kong KH, Kim HS, Kwack SJ, Kang TS, Kim SH, Kim HS, Lee J. Toxicol Lett. 2010 Mar 1;193(1):86-93. doi: 10.1016/j.toxlet.2009.12.015. Epub 2009 Dec 24.
- Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. Kim MS, Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, Kim SH, Lee J. Toxicology. 2009 Jun 16;260(1-3):97-103. doi: 10.1016/j.tox.2009.03.013. Epub 2009 Mar 27.
- Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis. Son TG, Park HR, Kim SJ, Kim K, Kim MS, Ishigami A, Handa S, Maruyama N, Chung HY, Lee J. J Neurosci Res. 2009 Oct;87(13):2890-7. doi: 10.1002/jnr.22122.
- Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J. J Biol Chem. 2008 May 23;283(21):14497-505. doi: 10.1074/jbc.M708373200. Epub 2008 Mar 24.
- Interferon-gamma promotes differentiation of neural progenitor cells via the JNK pathway. Kim SJ, Son TG, Kim K, Park HR, Mattson MP, Lee J. Neurochem Res. 2007 Aug;32(8):1399-406. Epub 2007 Apr 6.
- Diallyl disulfide impairs hippocampal neurogenesis in the young adult brain. Ji ST, Kim MS, Park HR, Lee E, Lee Y, Jang YJ, Kim HS, Lee J. Toxicol Lett. 2013 Jul 31;221(1):31-8. doi: 10.1016/j.toxlet.2013.05.013. Epub 2013 May 31.
- Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity. Chung JY, Park HR, Lee SJ, Lee SH, Kim JS, Jung YS, Hwang SH, Ha NC, Seol WG, Lee J, Park BJ. Lab Invest. 2013 Jun;93(6):663-76. doi: 10.1038/labinvest.2013.60. Epub 2013 Apr 22.
- Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption. Lee Y, Oh SB, Park HR, Kim HS, Kim MS, Lee J. Neurosci Lett. 2013 Feb 22;535:134-9. doi: 10.1016/j.neulet.2012.12.050. Epub 2013 Jan 8.
- Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation. Kim HS, Son TG, Park HR, Lee Y, Jung Y, Ishigami A, Lee J. Neurobiol Aging. 2013 Apr;34(4):1177-83. doi: 10.1016/j.neurobiolaging.2012.10.008. Epub 2012 Oct 31.
- Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. Park HR, Kong KH, Yu BP, Mattson MP, Lee J. J Biol Chem. 2012 Dec 14;287(51):42588-600. doi: 10.1074/jbc.M112.406413. Epub 2012 Oct 26.
- Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation. Oh SB, Park HR, Jang YJ, Choi SY, Son TG, Lee J.
Br J Pharmacol. 2013 Jan;168(2):421-31. doi: 10.1111/j.1476-5381.2012.02142.x.
- Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. Choi SY, Son TG, Park HR, Jang YJ, Oh SB, Jin B, Lee J. J Neurosci Res. 2012 Sep;90(9):1842-9. doi: 10.1002/jnr.23061. Epub 2012 Apr 19.
- High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Jang YJ, Park HR, Kim TH, Yang WJ, Lee JJ, Choi SY, Oh SB, Lee E, Park JH, Kim HP, Kim HS, Lee J. Toxicology. 2012 Jun 14;296(1-3):73-82. doi: 10.1016/j.tox.2012.03.007. Epub 2012 Apr 3.
- The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress. Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, Jeon HM, Kang KW, Kang HS, Chang SC, Kim HS, Chung HY, Lee J. Free Radic Res. 2012 Jan;46(1):21-9. doi: 10.3109/10715762.2011.636042. Epub 2011 Nov 22.
- Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Kim MS, Park HR, Chung HY, Kim HS, Yu BP, Yang HS, Lee J. Chem Biol Interact. 2011 Nov 15;194(2-3):139-47. doi: 10.1016/j.cbi.2011.10.001. Epub 2011 Oct 12.
- Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory. Kim ME, Park HR, Gong EJ, Choi SY, Kim HS, Lee J. Food Chem Toxicol. 2011 Dec;49(12):3383-9. doi: 10.1016/j.fct.2011.09.017. Epub 2011 Sep 19.
- Neurogenic contributions made by dietary regulation to hippocampal neurogenesis. Park HR, Lee J. Ann N Y Acad Sci. 2011 Jul;1229:23-8. doi: 10.1111/j.1749-6632.2011.06089.x. Review.
- Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Gong EJ, Park HR, Kim ME, Piao S, Lee E, Jo DG, Chung HY, Ha NC, Mattson MP, Lee J. Neurobiol Dis. 2011 Nov;44(2):223-30. doi: 10.1016/j.nbd.2011.07.005. Epub 2011 Jul 18.
- Lipotoxicity of palmitic Acid on neural progenitor cells and hippocampal neurogenesis.
Park HR, Kim JY, Park KY, Lee J. Toxicol Res. 2011 Jun;27(2):103-10. doi: 10.5487/TR.2011.27.2.103.
- Capsaicin impairs proliferation of neural progenitor cells and hippocampal neurogenesis in young mice. Kong KH, Kim HK, Song KS, Woo YS, Choi WS, Park HR, Park M, Kim ME, Kim MS, Ryu JS, Kim HS, Lee J. J Toxicol Environ Health A. 2010;73(21-22):1490-501. doi: 10.1080/15287394.2010.511572.
- A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. Park HR, Park M, Choi J, Park KY, Chung HY, Lee J. Neurosci Lett. 2010 Oct 4;482(3):235-9. doi: 10.1016/j.neulet.2010.07.046. Epub 2010 Jul 27.
- Risk assessment for the combinational effects of food color additives: neural progenitor cells and hippocampal neurogenesis. Park M, Park HR, Kim SJ, Kim MS, Kong KH, Kim HS, Gong EJ, Kim ME, Kim HS, Lee BM, Lee J. J Toxicol Environ Health A. 2009;72(21-22):1412-23. doi: 10.1080/15287390903212816.
- Potencies of bisphenol A on the neuronal differentiation and hippocampal neurogenesis. Kim K, Son TG, Park HR, Kim SJ, Kim HS, Kim HS, Kim TS, Jung KK, Han SY, Lee J. J Toxicol Environ Health A. 2009;72(21-22):1343-51. doi:10.1080/15287390903212501.
- Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis. Park HR, Kim MS, Kim SJ, Park M, Kong KH, Kim HS, Kwack SJ, Kang TS, Kim SH, Kim HS, Lee J. Toxicol Lett. 2010 Mar 1;193(1):86-93. doi: 10.1016/j.toxlet.2009.12.015. Epub 2009 Dec 24.
- Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. Kim MS, Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, Kim SH, Lee J. Toxicology. 2009 Jun 16;260(1-3):97-103. doi: 10.1016/j.tox.2009.03.013. Epub 2009 Mar 27.
- Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis. Son TG, Park HR, Kim SJ, Kim K, Kim MS, Ishigami A, Handa S, Maruyama N, Chung HY, Lee J. J Neurosci Res. 2009 Oct;87(13):2890-7. doi: 10.1002/jnr.22122.
- Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J. J Biol Chem. 2008 May 23;283(21):14497-505. doi: 10.1074/jbc.M708373200. Epub 2008 Mar 24.
- Interferon-gamma promotes differentiation of neural progenitor cells via the JNK pathway. Kim SJ, Son TG, Kim K, Park HR, Mattson MP, Lee J. Neurochem Res. 2007 Aug;32(8):1399-406. Epub 2007 Apr 6.